CPEB4 antibody (AA 244-515)

Catalog No. ABIN7149348

The Rabbit Polyclonal anti-CPEB4 antibody has been validated for ELISA, WB and IF. It is suitable to detect CPEB4 in samples from Human.

Quick Overview for CPEB4 antibody (AA 244-515) (ABIN7149348)

Target: CPEB4 (Cytoplasmic Polyadenylation Element Binding Protein 4 (CPEB4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPEB4 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-CPEB4 Antibody

Binding Specificity: AA 244-515

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cytoplasmic polyadenylation element-binding protein 4 protein (244-515AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CPEB4

Target: CPEB4 (Cytoplasmic Polyadenylation Element Binding Protein 4 (CPEB4))

Alternative Name: CPEB4

Background:

Background: Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5\\\'-UUUUUAU-3\\\') within the mRNA 3\\\'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity).

Aliases: CPE binding protein 4 antibody, CPE-binding protein 4 antibody, CPE-BP4 antibody, cpeb4 antibody, CPEB4_HUMAN antibody, Cytoplasmic polyadenylation element binding protein 4 antibody, Cytoplasmic polyadenylation element-binding protein 4 antibody, hCPEB-4 antibody, KIAA1673 antibody

UniProt: Q17RY0