NCK1 antibody (AA 58-377)

Catalog No. ABIN7149352

This anti-NCK1 antibody is a Rabbit Polyclonal antibody detecting NCK1 in WB, IHC and ELISA. Suitable for Human.

Quick Overview for NCK1 antibody (AA 58-377) (ABIN7149352)

Target: NCK1 (NCK Adaptor Protein 1 (NCK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-NCK1 Antibody

Binding Specificity: AA 58-377

Cross-Reactivity: Human, Rat

Purification: Antigen Affinity purified

Immunogen: Recombinant Human Cytoplasmic protein NCK1 protein (58-377AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NCK1

Target: NCK1 (NCK Adaptor Protein 1 (NCK1))

Alternative Name: NCK1

Background:

Background: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.

Aliases: Cytoplasmic protein NCK1 antibody, Melanoma Nck protein antibody, MGC12668 antibody, NCK 1 antibody, NCK adaptor protein 1 antibody, NCK alpha antibody, NCK antibody, NCK tyrosine kinase antibody, Nck-1 antibody, NCK1 antibody, NCK1_HUMAN antibody, NCKalpha antibody, Non catalytic region of tyrosine kinase antibody, SH2/SH3 adaptor protein NCK alpha antibody, SH2/SH3 adaptor protein NCK-alpha antibody

UniProt: P16333

Pathways: TCR Signaling, Regulation of Actin Filament Polymerization, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals