DOCK7 antibody (AA 1440-1671) (Biotin)

Catalog No. ABIN7149600

The Rabbit Polyclonal anti-DOCK7 antibody has been validated for ELISA. It is suitable to detect DOCK7 in samples from Human.

Quick Overview for DOCK7 antibody (AA 1440-1671) (Biotin) (ABIN7149600)

Target: DOCK7 (Dedicator of Cytokinesis 7 (DOCK7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOCK7 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-DOCK7 Antibody (Biotin)

Binding Specificity: AA 1440-1671

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Dedicator of cytokinesis protein 7 protein (1440-1671AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DOCK7

Target: DOCK7 (Dedicator of Cytokinesis 7 (DOCK7))

Alternative Name: DOCK7

Background:

Background: Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 \\\'Ser-15\\\' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation, negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity).

Aliases: DOCK7 antibody, KIAA1771Dedicator of cytokinesis protein 7 antibody

UniProt: Q96N67