SAMHD1 antibody (AA 1-314)

Catalog No. ABIN7149714

The Rabbit Polyclonal anti-SAMHD1 antibody has been validated for WB, ELISA and IHC. It is suitable to detect SAMHD1 in samples from Human.

Quick Overview for SAMHD1 antibody (AA 1-314) (ABIN7149714)

Target: SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SAMHD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-SAMHD1 Antibody

Binding Specificity: AA 1-314

Cross-Reactivity: Human

Purification: >95%, Antigen Affinity purified & Affinity purified

Immunogen: Recombinant Human Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 protein (1-314AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:100-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SAMHD1

Target: SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))

Alternative Name: SAMHD1

Background:

Background: Host restriction nuclease involved in defense response to virus. Has dNTPase activity and reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur. Blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May play a role in mediating proinflammatory responses to TNF-alpha signaling (PubMed:18546154, PubMed:19525956, PubMed:22056990, PubMed:24336198, PubMed:28229507). Has ribonuclease activity, acting on single-stranded RNA. This activity is essential for H1V-1 restriction (PubMed:25038827).

Aliases: CHBL2 antibody, DCIP antibody, Dendritic cell derived IFNG induced protein antibody, Dendritic cell-derived IFNG-induced protein antibody, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 antibody, dNTPase antibody, HD domain containing 1 antibody, HDDC1 antibody, Mg11 antibody, Monocyte protein 5 antibody, MOP 5 antibody, MOP-5 antibody, MOP5 antibody, OTTHUMP00000030889 antibody, SAM domain and HD domain 1 antibody, SAM domain and HD domain containing protein 1 antibody, SAM domain and HD domain-containing protein 1 antibody, SAMH1_HUMAN antibody, Samhd1 antibody, SBBI88 antibody

UniProt: Q9Y3Z3