DDIT3 antibody (AA 1-169) (Biotin)

Catalog No. ABIN7150133

This Rabbit Polyclonal antibody specifically detects DDIT3 in ELISA. It exhibits reactivity toward Human.

Quick Overview for DDIT3 antibody (AA 1-169) (Biotin) (ABIN7150133)

Target: DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDIT3 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-DDIT3 Antibody (Biotin)

Binding Specificity: AA 1-169

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human DNA damage-inducible transcript 3 protein (1-169AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DDIT3

Target: DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))

Alternative Name: DDIT3

Background:

Background: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates, expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.

Aliases: C/EBP homologous protein antibody, C/EBP Homology Protein antibody, C/EBP zeta antibody, C/EBP-homologous protein 10 antibody, C/EBP-homologous protein antibody, CCAAT/enhancer binding protein homologous protein antibody, CEBPZ antibody, CHOP 10 antibody, CHOP antibody, CHOP-10 antibody, CHOP10 antibody, DDIT 3 antibody, DDIT-3 antibody, Ddit3 antibody, DDIT3_HUMAN antibody, DNA Damage Inducible Transcript 3 antibody, DNA damage-inducible transcript 3 protein antibody, GADD 153 antibody, GADD153 antibody, Growth Arrest and DNA Damage Inducible Protein 153 antibody, Growth arrest and DNA damage inducible protein GADD153 antibody, Growth arrest and DNA damage-inducible protein GADD153 antibody, MGC4154 antibody

UniProt: P35638

Pathways: Regulation of Muscle Cell Differentiation, ER-Nucleus Signaling, Skeletal Muscle Fiber Development, Cell RedoxHomeostasis