CCDC111 antibody (AA 305-537)
Quick Overview for CCDC111 antibody (AA 305-537) (ABIN7150406)
Target
See all CCDC111 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 305-537
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Purpose
- PRIMPOL Antibody
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Purification
- Protein G purified
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Purity
- >95 %
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Immunogen
- Recombinant Human DNA-directed primase/polymerase protein (305-537AA)
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Isotype
- IgG
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anti-Coiled-Coil Domain Containing 111 (CCDC111) antibody
CCDC111 Reactivity: Human, Mouse, Rat IHC, IF, WB Host: Rabbit Polyclonal unconjugated
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- CCDC111 (Coiled-Coil Domain Containing 111 (CCDC111))
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Alternative Name
- PRIMPOL
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Background
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Background: DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. Required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. Has non-overlapping function with POLH.
Aliases: CC111_HUMAN antibody, CCDC111 antibody, Coiled coil domain containing 111 antibody, Coiled-coil domain-containing protein 111 antibody, DNA-directed primase/polymerase protein antibody, MYP22 antibody, Primase and polymerase (DNA directed) antibody, PRIMPOL antibody
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UniProt
- Q96LW4
Target
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