POLR2D antibody (AA 1-142)

Catalog No. ABIN7150434

The Rabbit Polyclonal anti-POLR2D antibody has been validated for ELISA. It is suitable to detect POLR2D in samples from Human.

Quick Overview for POLR2D antibody (AA 1-142) (ABIN7150434)

Target: POLR2D (Polymerase (RNA) II (DNA Directed) Polypeptide D (POLR2D))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLR2D antibody is un-conjugated

Application: ELISA

Product Details anti-POLR2D Antibody

Binding Specificity: AA 1-142

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human DNA-directed RNA polymerase II subunit RPB4 protein (1-142AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for POLR2D

Target: POLR2D (Polymerase (RNA) II (DNA Directed) Polypeptide D (POLR2D))

Alternative Name: POLR2D

Background:

Background: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA.

Aliases: DNA directed RNA polymerase II 16 kDa polypeptide antibody, DNA directed RNA polymerase II subunit D antibody, DNA directed RNA polymerase II subunit RPB4 antibody, DNA-directed RNA polymerase II 16 kDa polypeptide antibody, DNA-directed RNA polymerase II subunit D antibody, DNA-directed RNA polymerase II subunit rpb4 antibody, HSRBP4 antibody, HSRPB4 antibody, polr2d antibody, polymerase RNA II DNA directed polypeptide D antibody, RBP4 antibody, RNA polymerase II 16 kDa subunit antibody, RNA polymerase II subunit B4 antibody, RNA polymerase II subunit D antibody, RNA polymerase II subunit hsRBP4 antibody, RPB16 antibody, RPB4_HUMAN antibody

UniProt: O15514

Pathways: Regulatory RNA Pathways