STT3B antibody (AA 682-809)

Catalog No. ABIN7150607

This Rabbit Polyclonal antibody specifically detects STT3B in ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for STT3B antibody (AA 682-809) (ABIN7150607)

Target: STT3B (STT3, Subunit of The Oligosaccharyltransferase Complex, Homolog B (STT3B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STT3B antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-STT3B Antibody

Binding Specificity: AA 682-809

Purpose: STT3B Antibody

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B protein (682-809AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for STT3B

Target: STT3B (STT3, Subunit of The Oligosaccharyltransferase Complex, Homolog B (STT3B))

Alternative Name: STT3B

Background:

Background: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR \\\'Asp-38\\\' of TTR at \\\'Asn-118\\\', leading to its degradation.

Aliases: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B antibody, Homolog of yeast STT3 antibody, Oligosaccharyl transferase subunit STT3B antibody, SIMP antibody, source of immunodominant MHC associated peptides antibody, Source of immunodominant MHC-associated peptides homolog antibody, STT3 subunit of the oligosaccharyltransferase complex homolog B (S. cerevisiae) antibody, STT3 subunit of the oligosaccharyltransferase complex homolog B antibody, STT3-B antibody, Stt3b antibody, STT3B_HUMAN antibody

UniProt: Q8TCJ2