DMRT1 antibody (AA 195-363)

Catalog No. ABIN7150637

This Rabbit Polyclonal antibody specifically detects DMRT1 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for DMRT1 antibody (AA 195-363) (ABIN7150637)

Target: DMRT1 (Doublesex and Mab-3 Related Transcription Factor 1 (DMRT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DMRT1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-DMRT1 Antibody

Binding Specificity: AA 195-363

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Doublesex- and mab-3-related transcription factor 1 protein (195-363AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DMRT1

Target: DMRT1 (Doublesex and Mab-3 Related Transcription Factor 1 (DMRT1))

Alternative Name: DMRT1

Background:

Background: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).

Aliases: CT154 antibody, DM domain expressed in testis 1 antibody, DM domain expressed in testis protein 1 antibody, DM domain gene expressed in testis antibody, DMRT 1 antibody, dmrt1 antibody, DMRT1_HUMAN antibody, DMT 1 antibody, DMT1 antibody, Doublesex and mab 3 related transcription factor 1 antibody, Doublesex- and mab-3-related transcription factor 1 antibody

UniProt: Q9Y5R6