RNF2 antibody (AA 1-100) (Biotin)

Catalog No. ABIN7150988

This Rabbit Polyclonal antibody specifically detects RNF2 in ELISA. It exhibits reactivity toward Human.

Quick Overview for RNF2 antibody (AA 1-100) (Biotin) (ABIN7150988)

Target: RNF2 (Ring Finger Protein 2 (RNF2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF2 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-RNF2 Antibody (Biotin)

Binding Specificity: AA 1-100

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase BRE1A protein (1-100AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RNF2

Target: RNF2 (Ring Finger Protein 2 (RNF2))

Alternative Name: RNF2

Background:

Background: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of \\\'Lys-120\\\' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 \\\'Lys-4\\\' and \\\'Lys-79\\\' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B, reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.

Aliases: BRE1 A antibody, BRE1 antibody, BRE1 E3 ubiquitin ligase homolog antibody, BRE1-A antibody, BRE1A antibody, BRE1A_HUMAN antibody, E3 ubiquitin-protein ligase BRE1A antibody, hBRE1 antibody, Homolog of S. cerevisiae BRE1 antibody, RING finger protein 20 antibody, Ring finger protein 20 E3 ubiquitin protein ligase antibody, Rnf20 antibody

UniProt: Q5VTR2