Deltex Homolog 1 antibody (AA 261-410)

Catalog No. ABIN7151013

The Rabbit Polyclonal anti-Deltex Homolog 1 antibody has been validated for ELISA and IF. It is suitable to detect Deltex Homolog 1 in samples from Human.

Quick Overview for Deltex Homolog 1 antibody (AA 261-410) (ABIN7151013)

Target: Deltex Homolog 1 (DTX1) (E3 Ubiquitin-protein ligase DTX1 (DTX1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Deltex Homolog 1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Product Details anti-Deltex Homolog 1 Antibody

Binding Specificity: AA 261-410

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase DTX1 protein (261-410AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Deltex Homolog 1

Target: Deltex Homolog 1 (DTX1) (E3 Ubiquitin-protein ligase DTX1 (DTX1))

Alternative Name: DTX1

Background:

Background: Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.

Aliases: Deltex 1, E3 ubiquitin ligase antibody, Deltex antibody, Deltex homolog 1 (Drosophila) antibody, Deltex homolog 1 antibody, Deltex protein 1 antibody, Deltex-1 antibody, Deltex1 antibody, dtx1 antibody, DTX1_HUMAN antibody, E3 ubiquitin protein ligase DTX1 antibody, E3 ubiquitin-protein ligase DTX1 antibody, FXI-T1 antibody, Fxit 1 antibody, Fxit1 antibody, hDTX1 antibody, hDx 1 antibody, mDTX1 antibody, Protein deltex 1 antibody, Protein deltex-1 antibody

UniProt: Q86Y01

Pathways: Notch Signaling