RNF139 antibody (AA 510-664)

Catalog No. ABIN7151154

The Rabbit Polyclonal anti-RNF139 antibody has been validated for ELISA and IHC. It is suitable to detect RNF139 in samples from Human.

Quick Overview for RNF139 antibody (AA 510-664) (ABIN7151154)

Target: RNF139 (Ring Finger Protein 139 (RNF139))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF139 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-RNF139 Antibody

Binding Specificity: AA 510-664

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase RNF139 protein (510-664AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RNF139

Target: RNF139 (Ring Finger Protein 139 (RNF139))

Alternative Name: RNF139

Background:

Background: E3-ubiquitin ligase, acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor.

Aliases: RNF139 antibody, TRC8 antibody, E3 ubiquitin-protein ligase RNF139 antibody, EC 2.3.2.27 antibody, RING finger protein 139 antibody, RING-type E3 ubiquitin transferase RNF139 antibody, Translocation in renal carcinoma on chromosome 8 protein antibody

UniProt: Q8WU17