RNF34 antibody (AA 1-220)

Catalog No. ABIN7151192

This Rabbit Polyclonal antibody specifically detects RNF34 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for RNF34 antibody (AA 1-220) (ABIN7151192)

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF34 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-RNF34 Antibody

Binding Specificity: AA 1-220

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase RNF34 protein (1-220AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RNF34

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Alternative Name: RNF34

Background:

Background: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate \\\'Lys-48\\\'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through \\\'Lys-48\\\'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219).

Aliases: CARP 1 antibody, CARP-1 antibody, CARP1 antibody, Caspase regulator CARP1 antibody, Caspases-8 and -10-associated RING finger protein 1 antibody, E3 ubiquitin-protein ligase RNF34 antibody, FYVE-RING finger protein Momo antibody, hRFI antibody, Human RING finger homologous to inhibitor of apoptosis protein antibody, RFI antibody, RIF antibody, RIFF antibody, RING finger protein 34 antibody, RING finger protein RIFF antibody, RNF34 antibody, RNF34_HUMAN antibody

UniProt: Q969K3