RNF43 antibody (AA 566-697)

Catalog No. ABIN7151198

This Rabbit Polyclonal antibody specifically detects RNF43 in ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for RNF43 antibody (AA 566-697) (ABIN7151198)

Target: RNF43 (Ring Finger Protein 43 (RNF43))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF43 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-RNF43 Antibody

Binding Specificity: AA 566-697

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase RNF43 protein (566-697AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RNF43

Target: RNF43 (Ring Finger Protein 43 (RNF43))

Alternative Name: RNF43

Background:

Background: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.

Aliases: RNF43 antibody, E3 ubiquitin-protein ligase RNF43 antibody, EC 2.3.2.27 antibody, RING finger protein 43 antibody, RING-type E3 ubiquitin transferase RNF43 antibody

UniProt: Q68DV7

Pathways: WNT Signaling