SMURF1 antibody (AA 198-374)

Catalog No. ABIN7151222

This Rabbit Polyclonal antibody specifically detects SMURF1 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for SMURF1 antibody (AA 198-374) (ABIN7151222)

Target: SMURF1 (SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMURF1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-SMURF1 Antibody

Binding Specificity: AA 198-374

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase SMURF1 protein (198-374AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SMURF1

Target: SMURF1 (SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1))

Alternative Name: SMURF1

Background:

Background: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Aliases: E3 ubiquitin-protein ligase SMURF1 antibody, hSMURF1 antibody, KIAA1625 antibody, Smad specific E3 ubiquitin ligase 1 antibody, SMAD specific E3 ubiquitin protein ligase 1 antibody, Smad ubiquitination regulatory factor 1 antibody, SMAD-specific E3 ubiquitin-protein ligase 1 antibody, SMUF1_HUMAN antibody, SMURF 1 antibody, smurf1 antibody

UniProt: Q9HCE7

Pathways: Regulation of Cell Size