TRIM25 antibody (AA 81-272) (Biotin)

Catalog No. ABIN7151323

This anti-TRIM25 antibody is a Rabbit Polyclonal antibody detecting TRIM25 in ELISA. Suitable for Human.

Quick Overview for TRIM25 antibody (AA 81-272) (Biotin) (ABIN7151323)

Target: TRIM25 (Tripartite Motif Containing 25 (TRIM25))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM25 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-TRIM25 Antibody (Biotin)

Binding Specificity: AA 81-272

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin/ISG15 ligase TRIM25 protein (81-272AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TRIM25

Target: TRIM25 (Tripartite Motif Containing 25 (TRIM25))

Alternative Name: TRIM25

Background:

Background: Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates \'Lys-63\'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784).

Aliases: E3 ubiquitin/ISG15 ligase TRIM25 antibody, EFP antibody, Estrogen responsive finger protein antibody, Estrogen-responsive finger protein antibody, RING finger protein 147 antibody, RNF 147 antibody, RNF147 antibody, TRI25 antibody, TRI25_HUMAN antibody, TRIM 25 antibody, Trim25 antibody, Tripartite motif containing 25 antibody, Tripartite motif containing protein 25 antibody, Tripartite motif protein TRIM25 antibody, Tripartite motif-containing protein 25 antibody, Tripartite motifcontaining25 antibody, Ubiquitin/ISG15-conjugating enzyme TRIM25 antibody, Z147 antibody, Zinc finger protein 147 (estrogen responsive finger protein) antibody, Zinc finger protein 147 antibody, Zinc finger protein-147 antibody, ZNF 147 antibody, ZNF147 antibody

UniProt: Q14258