EDEM1 antibody (AA 46-128) (Biotin)

Catalog No. ABIN7151971

The Biotin-conjugated Rabbit Polyclonal anti-EDEM1 antibody (ABIN7151971) specifically detects EDEM1 in ELISA. The antibody is reactive with Human samples.

Quick Overview for EDEM1 antibody (AA 46-128) (Biotin) (ABIN7151971)

Target: EDEM1 (ER Degradation Enhancer, Mannosidase alpha-Like 1 (EDEM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EDEM1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-EDEM1 Antibody (Biotin)

Binding Specificity: AA 46-128

Purpose: EDEM1 Antibody, Biotin conjugated

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human ER degradation-enhancing alpha-mannosidase-like protein 1 protein (46-128AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EDEM1

Target: EDEM1 (ER Degradation Enhancer, Mannosidase alpha-Like 1 (EDEM1))

Alternative Name: EDEM1

Background:

Background: Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.

Aliases: EDEM1 antibody, EDEM antibody, KIAA0212ER degradation-enhancing alpha-mannosidase-like protein 1 antibody

UniProt: Q92611

Pathways: ER-Nucleus Signaling