Exportin 2 antibody (AA 713-971)

Catalog No. ABIN7152321

The Rabbit Polyclonal anti-Exportin 2 antibody has been validated for WB, ELISA, IF and IHC. It is suitable to detect Exportin 2 in samples from Human.

Quick Overview for Exportin 2 antibody (AA 713-971) (ABIN7152321)

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Exportin 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Product Details anti-Exportin 2 Antibody

Binding Specificity: AA 713-971

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Exportin-2 protein (713-971AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Exportin 2

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Alternative Name: CSE1L

Background:

Background: Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Aliases: CAS antibody, Cellular apoptosis susceptibility protein antibody, Chromosome segregation 1 (yeast homolog) like antibody, Chromosome segregation 1 Like antibody, Chromosome segregation 1 like protein antibody, Chromosome segregation 1-like protein antibody, Chromosome segregation gene CSE1 antibody, CSE 1 antibody, CSE 1 chromosome segregation 1 like antibody, CSE 1 chromosome segregation 1 like protein antibody, CSE 1L antibody, CSE1 antibody, CSE1 chromosome segregation 1 like (yeast) antibody, CSE1 chromosome segregation 1 like antibody, CSE1 chromosome segregation 1 like protein antibody, CSE1L antibody, Exp 2 antibody, Exp2 antibody, Exportin 2 antibody, Exportin-2 antibody, Exportin2 antibody, Importin alpha re exporter antibody, Importin-alpha re-exporter antibody, MGC117283 antibody, MGC130036 antibody, MGC130037 antibody, XPO 2 antibody, XPO2 antibody, XPO2_HUMAN antibody

UniProt: P55060

Pathways: Protein targeting to Nucleus