EYA3 antibody (AA 1-300)

Catalog No. ABIN7152363

The Rabbit Polyclonal anti-EYA3 antibody has been validated for WB, IHC and ELISA. It is suitable to detect EYA3 in samples from Human.

Quick Overview for EYA3 antibody (AA 1-300) (ABIN7152363)

Target: EYA3 (Eyes Absent Homolog 3 (EYA3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EYA3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-EYA3 Antibody

Binding Specificity: AA 1-300

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Eyes absent homolog 3 protein (1-300AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EYA3

Target: EYA3 (Eyes Absent Homolog 3 (EYA3))

Alternative Name: EYA3

Background:

Background: Tyrosine phosphatase that specifically dephosphorylates \\\'Tyr-142\\\' of histone H2AX (H2AXY142ph). \\\'Tyr-142\\\' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye.

Aliases: AI844637 antibody, DKFZp686C132 antibody, EYA3 antibody, EYA3_HUMAN antibody, Eyes absent 3 antibody, Eyes absent 3 homolog (Drosophila) antibody, Eyes absent homolog 3 antibody, OTTMUSP00000010370 antibody, RP11-460I13.4 antibody, RP23-442A20.1 antibody

UniProt: Q99504

Pathways: Positive Regulation of Response to DNA Damage Stimulus