FOXL2 antibody (AA 116-216) (Biotin)

Catalog No. ABIN7153063

This anti-FOXL2 antibody is a Rabbit Polyclonal antibody detecting FOXL2 in ELISA. Suitable for Human.

Quick Overview for FOXL2 antibody (AA 116-216) (Biotin) (ABIN7153063)

Target: FOXL2 (Forkhead Box L2 (FOXL2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXL2 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-FOXL2 Antibody (Biotin)

Binding Specificity: AA 116-216

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Forkhead box protein L2 protein (116-216AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FOXL2

Target: FOXL2 (Forkhead Box L2 (FOXL2))

Alternative Name: FOXL2

Background:

Background: Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.

Aliases: Blepharophimosis antibody, Blepharophimosis epicanthus inversus and ptosis 1 antibody, Blepharophimosis epicanthus inversus and ptosis antibody, BPES 1 antibody, BPES antibody, BPES1 antibody, Epicanthus inversus and ptosis 1 antibody, Forkhead box L2 antibody, Forkhead box protein L2 antibody, Forkhead transcription factor FOXL2 antibody, FOX L2 antibody, FOXL 2 antibody, FOXL2 antibody, FOXL2_HUMAN antibody, PFRK antibody, PINTO antibody, PITUITARY FORKHEAD FACTOR antibody, POF 3 antibody, POF3 antibody

UniProt: P58012

Pathways: Nuclear Hormone Receptor Binding, Positive Regulation of Endopeptidase Activity