FZD8 antibody (AA 55-233) (HRP)

Catalog No. ABIN7153196

This Rabbit Polyclonal antibody specifically detects FZD8 in ELISA. It exhibits reactivity toward Human.

Quick Overview for FZD8 antibody (AA 55-233) (HRP) (ABIN7153196)

Target: FZD8 (Frizzled Family Receptor 8 (FZD8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FZD8 antibody is conjugated to HRP

Application: ELISA

Product Details anti-FZD8 Antibody (HRP)

Binding Specificity: AA 55-233

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Frizzled-8 protein (55-233AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FZD8

Target: FZD8 (Frizzled Family Receptor 8 (FZD8))

Alternative Name: FZD8

Background:

Background: Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

Aliases: Frizzled 8 seven transmembrane spanning receptor antibody, frizzled 8, seven transmembrane spanning receptor antibody, Frizzled family receptor 8 antibody, frizzled homolog 8 (Drosophila) antibody, Frizzled homolog 8 antibody, Frizzled-8 antibody, FZ 8 antibody, Fz-8 antibody, FZ8 antibody, FZD 8 antibody, FZD8 antibody, FZD8_HUMAN antibody, hFZ 8 antibody, hFz8 antibody, HGNC4046 antibody, Homolog of Drosophila Frizzled 8 antibody

UniProt: Q9H461

Pathways: WNT Signaling