Mare/Nprl3/C16orf35 antibody (AA 349-482) (Biotin)

Catalog No. ABIN7153702

This anti-Mare/Nprl3/C16orf35 antibody is a Rabbit Polyclonal antibody detecting Mare/Nprl3/C16orf35 in ELISA. Suitable for Human.

Quick Overview for Mare/Nprl3/C16orf35 antibody (AA 349-482) (Biotin) (ABIN7153702)

Target: Mare/Nprl3/C16orf35 (C16orf35) (MARE (C16orf35))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Mare/Nprl3/C16orf35 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-Mare/Nprl3/C16orf35 Antibody (Biotin)

Binding Specificity: AA 349-482

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human GATOR complex protein NPRL3 protein (349-482AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Mare/Nprl3/C16orf35

Target: Mare/Nprl3/C16orf35 (C16orf35) (MARE (C16orf35))

Alternative Name: NPRL3

Background:

Background: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.

Aliases: otein antibody, Alpha-globin regulatory element-containing gene protein antibody, C16ORF35 antibody, CGTHBA antibody, Conserved gene telomeric to alpha globin cluster antibody, HS 40 antibody, MARE antibody, Nitrogen permease regulator 3-like protein antibody, Nitrogen permease regulator-like 3 (S. cerevisiae) antibody, NPR3 antibody, NPRL3 antibody, NPRL3_HUMAN antibody, Protein CGTHBA antibody, RMD11 antibody

UniProt: Q12980