GPC1 antibody (AA 342-530) (HRP)

Catalog No. ABIN7154267

This Rabbit Polyclonal antibody specifically detects GPC1 in ELISA. It exhibits reactivity toward Human.

Quick Overview for GPC1 antibody (AA 342-530) (HRP) (ABIN7154267)

Target: GPC1 (Glypican 1 (GPC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPC1 antibody is conjugated to HRP

Application: ELISA

Product Details anti-GPC1 Antibody (HRP)

Binding Specificity: AA 342-530

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Glypican-1 protein (342-530AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GPC1

Target: GPC1 (Glypican 1 (GPC1))

Alternative Name: GPC1

Background:

Background: Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.

Aliases: FLJ38078 antibody, glypican antibody, Glypican proteoglycan 1 antibody, glypican1 antibody, GPC 1 antibody, Gpc1 antibody, GPC1_HUMAN antibody, Secreted glypican-1 antibody

UniProt: P35052

Pathways: Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation