GREM1 antibody (AA 18-184) (Biotin)

Catalog No. ABIN7154449

This anti-GREM1 antibody is a Rabbit Polyclonal antibody detecting GREM1 in ELISA. Suitable for Human.

Quick Overview for GREM1 antibody (AA 18-184) (Biotin) (ABIN7154449)

Target: GREM1 (Gremlin 1 (GREM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GREM1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-GREM1 Antibody (Biotin)

Binding Specificity: AA 18-184

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Gremlin-1 protein (18-184AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GREM1

Target: GREM1 (Gremlin 1 (GREM1))

Alternative Name: GREM1

Background:

Background: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2, inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed:27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity).

Aliases: BMP antagonist 1 antibody, Cell proliferation inducing gene 2 protein antibody, Cell proliferation-inducing gene 2 protein antibody, CKTSF1B1 antibody, colorectal adenoma and carcinoma 1 antibody, Cysteine knot superfamily 1 antibody, Cysteine knot superfamily 1, BMP antagonist 1 antibody, Cysteine knot superfamily BMP antagonist 1 antibody, DAN domain family member 2 antibody, DAND2 antibody, Down regulated in Mos-transformed cells protein antibody, Down-regulated in Mos-transformed cells protein antibody, DRM antibody, grem1 antibody, GREM1_HUMAN antibody, Gremlin 1 homolog, cysteine knot superfamily antibody, Gremlin 1 like protein antibody, Gremlin 1, cysteine knot superfamily, homolog antibody, GREMLIN antibody, Gremlin-1 antibody, Gremlin1 antibody, IHG-2 antibody, IHG2 antibody, Increased in high glucose 2 antibody, Increased in high glucose protein 2 antibody, PIG2 antibody, Proliferation inducing gene 2 antibody, proliferation inducing gene 2 protein antibody

UniProt: O60565

Pathways: Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location