PDE9A antibody (AA 426-533) (Biotin)

Catalog No. ABIN7155176

This Rabbit Polyclonal antibody specifically detects PDE9A in ELISA. It exhibits reactivity toward Human.

Quick Overview for PDE9A antibody (AA 426-533) (Biotin) (ABIN7155176)

Target: PDE9A (phosphodiesterase 9A (PDE9A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE9A antibody is conjugated to Biotin

Application: ELISA

Product Details anti-PDE9A Antibody (Biotin)

Binding Specificity: AA 426-533

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human High affinity cGMP-specific 3\',5\'-cyclic phosphodiesterase 9A protein (426-533AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PDE9A

Target: PDE9A (phosphodiesterase 9A (PDE9A))

Alternative Name: PDE9A

Background:

Background: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity).

Aliases: 5''-cyclic phosphodiesterase 9A antibody, cGMP specific 3' 5' cyclic phosphodiesterase type 9 antibody, FLJ90181 antibody, High affinity cGMP-specific 3'' antibody, High-affinity cGMP-specific 3'5'-cyclic phosphodiesterase 9A antibody, HSPDE9A2 antibody, OTTHUMP00000109399 antibody, PDE 9A antibody, Pde9a antibody, PDE9A_HUMAN antibody, Phosphodiesterase 9A antibody, phosphodiesterase PDE9A21 antibody

UniProt: O76083