HINT1 antibody (AA 2-126)

Catalog No. ABIN7155253

This anti-HINT1 antibody is a Rabbit Polyclonal antibody detecting HINT1 in ELISA, IHC and IF. Suitable for Human.

Quick Overview for HINT1 antibody (AA 2-126) (ABIN7155253)

Target: HINT1 (Histidine Triad Nucleotide Binding Protein 1 (HINT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HINT1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-HINT1 Antibody

Binding Specificity: AA 2-126

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Histidine triad nucleotide-binding protein 1 protein (2-126AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HINT1

Target: HINT1 (Histidine Triad Nucleotide Binding Protein 1 (HINT1))

Alternative Name: HINT1

Background:

Background: Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5\\\'monophosphoramidate (AMP-NH2), adenosine 5\\\'monophosphomorpholidate (AMP-morpholidate) and guanosine 5\\\'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5\\\'-O-phosphorothioate and guanosine 5\\\'-O-phosphorothioate to the corresponding nucleoside 5\\\'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.

Aliases: Adenosine 5' monophosphoramidase antibody, Adenosine 5''-monophosphoramidase antibody, HINT 1 antibody, HINT1 antibody, HINT1_HUMAN antibody, Histidine triad nucleotide binding protein 1 antibody, Histidine triad nucleotide-binding protein 1 antibody, PKCI 1 antibody, PKCI-1 antibody, PKCI1 antibody, PRKCNH1 antibody, Protein kinase C inhibitor 1 antibody, Protein kinase C interacting protein 1 antibody, Protein kinase C-interacting protein 1 antibody

UniProt: P49773