HDAC6 antibody (AA 160-470)

Catalog No. ABIN7155322

This anti-HDAC6 antibody is a Rabbit Polyclonal antibody detecting HDAC6 in IHC and ELISA. Suitable for Human.

Quick Overview for HDAC6 antibody (AA 160-470) (ABIN7155322)

Target: HDAC6 (Histone Deacetylase 6 (HDAC6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC6 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-HDAC6 Antibody

Binding Specificity: AA 160-470

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Histone deacetylase 6 protein (160-470AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HDAC6

Target: HDAC6 (Histone Deacetylase 6 (HDAC6))

Alternative Name: HDAC6

Background:

Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

Aliases: CPBHM antibody, FLJ16239 antibody, HD 6 antibody, HD6 antibody, HDAC 6 antibody, HDAC6 antibody, HDAC6_HUMAN antibody, Histone deacetylase 6 (HD6) antibody, Histone deacetylase 6 antibody, JM 21 antibody, JM21 antibody, KIAA0901 antibody, OTTHUMP00000032398 antibody, OTTHUMP00000197663 antibody, PPP1R90 antibody, Protein phosphatase 1 regulatory subunit 90 antibody

UniProt: Q9UBN7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling