PAK6 antibody (pSer165) (HRP)

Catalog No. ABIN711320

The Rabbit Polyclonal anti-PAK6 antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect PAK6 in samples from Human and Mouse.

Quick Overview for PAK6 antibody (pSer165) (HRP) (ABIN711320)

Target: PAK6 (P21-Activated Kinase 6 (PAK6))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAK6 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-PAK6 Antibody (HRP)

Binding Specificity: pSer165

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human PAK6 around the phosphorylation site of Ser165

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PAK6

Target: PAK6 (P21-Activated Kinase 6 (PAK6))

Alternative Name: PAK6

Background:

Synonyms: PAK6phospho S165, CDKN1A activated kinase 6, p21 activated protein kinase 6, p21 protein Cdc42/Rac-activated kinase 6, p21CDKN1A activated kinase 6, p21-ACTIVATED KINASE 6, p21activated kinase 6, PAK 5, PAK 6, PAK5, Serine threonine protein kinase PAK 6, Serine/threonine protein kinase PAK 6, Serine/threonine protein kinase PAK6.

Background: This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.

Gene ID: 56924