MEOX1 antibody (AA 1-254)

Catalog No. ABIN7155798

The Rabbit Polyclonal anti-MEOX1 antibody has been validated for ELISA and IHC. It is suitable to detect MEOX1 in samples from Human.

Quick Overview for MEOX1 antibody (AA 1-254) (ABIN7155798)

Target: MEOX1 (Mesenchyme Homeobox 1 (MEOX1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEOX1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-MEOX1 Antibody

Binding Specificity: AA 1-254

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Homeobox protein MOX-1 protein (1-254AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MEOX1

Target: MEOX1 (Mesenchyme Homeobox 1 (MEOX1))

Alternative Name: MEOX1

Background:

Background: Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.

Aliases: Homeobox protein MOX-1 antibody, MEOX1 antibody, MEOX1_HUMAN antibody, Mesenchyme homeo box 1 antibody, Mesenchyme homeobox 1 antibody, MOX 1 antibody, MOX1 antibody

UniProt: P50221

Pathways: Chromatin Binding