HORMAD2 antibody (AA 14-307) (Biotin)

Catalog No. ABIN7155902

This Rabbit Polyclonal antibody specifically detects HORMAD2 in ELISA. It exhibits reactivity toward Human.

Quick Overview for HORMAD2 antibody (AA 14-307) (Biotin) (ABIN7155902)

Target: HORMAD2 (HORMA Domain Containing 2 (HORMAD2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HORMAD2 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-HORMAD2 Antibody (Biotin)

Binding Specificity: AA 14-307

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human HORMA domain-containing protein 2 protein (14-307AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HORMAD2

Target: HORMAD2 (HORMA Domain Containing 2 (HORMAD2))

Alternative Name: HORMAD2

Background:

Background: Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation.

Aliases: 4930529M09Rik antibody, CT46.2 antibody, HORM2_HUMAN antibody, HORMA domain containing 2 antibody, HORMA domain-containing protein 2 antibody, Hormad2 antibody, MGC26710 antibody, RP23-329P17.4 antibody

UniProt: Q8N7B1