ITPR1 antibody (AA 1707-1966)

Catalog No. ABIN7156293

The Rabbit Polyclonal anti-ITPR1 antibody has been validated for ELISA, IHC and IF. It is suitable to detect ITPR1 in samples from Human.

Quick Overview for ITPR1 antibody (AA 1707-1966) (ABIN7156293)

Target: ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITPR1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-ITPR1 Antibody

Binding Specificity: AA 1707-1966

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Inositol 1,4,5-trisphosphate receptor type 1 protein (1707-1966AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ITPR1

Target: ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))

Alternative Name: ITPR1

Background:

Background: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).

Aliases: 4 antibody, 5-trisphosphate receptor antibody, 5-trisphosphate receptor type 1 antibody, DKFZp313E1334 antibody, DKFZp313N1434 antibody, inositol 1 4 5 triphosphate receptor type 1 antibody, Inositol 1 4 5 trisphosphate Receptor Type 1 antibody, Inositol 1 antibody, InsP3R1 antibody, IP3 antibody, IP3 receptor antibody, IP3 receptor isoform 1 antibody, IP3R 1 antibody, IP3R antibody, IP3R1 antibody, ITPR 1 antibody, Itpr1 antibody, ITPR1_HUMAN antibody, SCA15 antibody, SCA16 antibody, SCA29 antibody, Type 1 inositol 1 4 5 trisphosphate receptor antibody, Type 1 inositol 1 antibody, Type 1 InsP3 receptor antibody

UniProt: Q14643

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, Synaptic Membrane, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma