IRF8 antibody (AA 137-426)

Catalog No. ABIN7156635

The Rabbit Polyclonal anti-IRF8 antibody has been validated for ELISA and IHC. It is suitable to detect IRF8 in samples from Human.

Quick Overview for IRF8 antibody (AA 137-426) (ABIN7156635)

Target: IRF8 (Interferon Regulatory Factor 8 (IRF8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF8 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-IRF8 Antibody

Binding Specificity: AA 137-426

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Interferon regulatory factor 8 protein (137-426AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IRF8

Target: IRF8 (Interferon Regulatory Factor 8 (IRF8))

Alternative Name: IRF8

Background:

Background: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5\\\'-TGAnTCA/GAAA-3\\\'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes.

Aliases: H ICSBP antibody, H-ICSBP antibody, HGNC:5358 antibody, HICSBP antibody, ICSBP 1 antibody, ICSBP antibody, ICSBP1 antibody, Interferon consensus sequence binding protein 1 antibody, Interferon consensus sequence binding protein antibody, Interferon consensus sequence-binding protein antibody, Interferon regulatory factor 8 antibody, IRF 8 antibody, IRF-8 antibody, Irf8 antibody, IRF8_HUMAN antibody, MYLS antibody

UniProt: Q02556

Pathways: Cellular Response to Molecule of Bacterial Origin