EBI3 antibody (AA 21-227)

Catalog No. ABIN7156880

This Rabbit Polyclonal antibody specifically detects EBI3 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for EBI3 antibody (AA 21-227) (ABIN7156880)

Target: EBI3 (IL-27b) (Interleukin-27 subunit beta (IL-27b))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EBI3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-EBI3 Antibody

Binding Specificity: AA 21-227

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Interleukin-27 subunit beta protein (21-227AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EBI3

Target: EBI3 (IL-27b) (Interleukin-27 subunit beta (IL-27b))

Alternative Name: EBI3

Background:

Background: Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.

Aliases: cytokine receptor antibody, EBI3 antibody, EBV induced gene 3 protein antibody, EBV-induced gene 3 protein antibody, Epstein Barr virus induced 3 antibody, Epstein Barr virus induced gene 3 antibody, Epstein Barr virus induced gene 3 protein antibody, Epstein-Barr virus-induced gene 3 protein antibody, IL 27 subunit beta antibody, IL 27B antibody, IL-27 subunit beta antibody, IL-27B antibody, IL27 subunit antibody, IL27 subunit beta antibody, IL27B antibody, IL27B_HUMAN antibody, IL35 subunit antibody, interleukin 27 subunit beta antibody, Interleukin-27 subunit beta antibody

UniProt: Q14213