ITSN1 antibody (AA 773-916) (HRP)

Catalog No. ABIN7156952

This Rabbit Polyclonal antibody specifically detects ITSN1 in ELISA. It exhibits reactivity toward Human.

Quick Overview for ITSN1 antibody (AA 773-916) (HRP) (ABIN7156952)

Target: ITSN1 (Intersectin 1 (ITSN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITSN1 antibody is conjugated to HRP

Application: ELISA

Product Details anti-ITSN1 Antibody (HRP)

Binding Specificity: AA 773-916

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Intersectin-1 protein (773-916AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ITSN1

Target: ITSN1 (Intersectin 1 (ITSN1))

Alternative Name: ITSN1

Background:

Background: Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR), internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.

Aliases: Human intersectin SH3 domain containing protein SH3P17 antibody, Intersectin 1 SH3 domain protein antibody, intersectin 1 short form variant 3 antibody, intersectin 1 short form variant, 11 antibody, Intersectin short form antibody, intersectin short variant 12 antibody, Intersectin-1 antibody, Intersectin1 antibody, ITSN 1 antibody, ITSN antibody, itsn1 antibody, ITSN1_HUMAN antibody, MGC134948 antibody, MGC134949 antibody, OTTHUMP00000067855 antibody, OTTHUMP00000067856 antibody, OTTHUMP00000067857 antibody, OTTHUMP00000194810 antibody, OTTHUMP00000194811 antibody, OTTHUMP00000194812 antibody, OTTHUMP00000206688 antibody, SH3 domain containing protein 1A antibody, SH3 domain protein 1A antibody, SH3 domain-containing protein 1A antibody, SH3D1A antibody, SH3P17 antibody, Src homology 3 domain containing protein antibody

UniProt: Q15811

Pathways: Neurotrophin Signaling Pathway