ISCU antibody (AA 1-167)

Catalog No. ABIN7157058

The Rabbit Polyclonal anti-ISCU antibody has been validated for ELISA and IHC. It is suitable to detect ISCU in samples from Human.

Quick Overview for ISCU antibody (AA 1-167) (ABIN7157058)

Target: ISCU (Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ISCU antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-ISCU Antibody

Binding Specificity: AA 1-167

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Iron-sulfur cluster assembly enzyme ISCU, mitochondrial protein (1-167AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ISCU

Target: ISCU (Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU))

Alternative Name: ISCU

Background:

Background: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins (PubMed:11060020). First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-LYRM4/ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity).

Aliases: 2310020H20Rik antibody, HML antibody, hnifU antibody, Iron sulfur cluster assembly enzyme ISCU mitochondrial antibody, Iron sulfur cluster scaffold homolog (E. coli) antibody, Iron sulfur cluster scaffold homolog antibody, Iron-sulfur cluster assembly enzyme ISCU antibody, Iscu antibody, IscU iron sulfur cluster scaffold homolog antibody, ISCU_HUMAN antibody, ISU2 antibody, MGC74517 antibody, mitochondrial antibody, NIFU antibody, NifU like N terminal domain containing antibody, NifU like N terminal domain containing protein antibody, NifU like protein antibody, NifU-like N-terminal domain-containing protein antibody, NifU-like protein antibody, NIFUN antibody, Nitrogen fixation cluster like antibody, OTTHUMP00000238760 antibody, OTTHUMP00000238761 antibody, OTTHUMP00000238762 antibody, OTTHUMP00000238764 antibody, OTTHUMP00000238765 antibody

UniProt: Q9H1K1