IST1 antibody (AA 172-284)

Catalog No. ABIN7157138

This Rabbit Polyclonal antibody specifically detects IST1 in ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for IST1 antibody (AA 172-284) (ABIN7157138)

Target: IST1 (Increased Sodium Tolerance 1 Homolog (IST1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IST1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-IST1 Antibody

Binding Specificity: AA 172-284

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human IST1 homolog protein (172-284AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IST1

Target: IST1 (Increased Sodium Tolerance 1 Homolog (IST1))

Alternative Name: IST1

Background:

Background: ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).

Aliases: hIST1 antibody, Increased sodium tolerance 1 antibody, Increased sodium tolerance 1 homolog antibody, IST1 homolog antibody, IST1_HUMAN antibody, KIAA0174 antibody, MAPK activating protein PM28 antibody, MGC117220 antibody, MGC128433 antibody, Putative MAPK-activating protein PM28 antibody

UniProt: P53990

Pathways: Regulation of Cell Size