KLHL12 antibody (AA 1-220)

Catalog No. ABIN7157267

This Rabbit Polyclonal antibody specifically detects KLHL12 in ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for KLHL12 antibody (AA 1-220) (ABIN7157267)

Target: KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLHL12 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-KLHL12 Antibody

Binding Specificity: AA 1-220

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Kelch-like protein 12 protein (1-220AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KLHL12

Target: KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))

Alternative Name: KLHL12

Background:

Background: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4.

Aliases: C3IP1 antibody, CUL3 interacting protein 1 antibody, CUL3-interacting protein 1 antibody, DKIR antibody, DKIR homolog antibody, FLJ27152 antibody, hDKIR antibody, Kelch like 12 (Drosophila) antibody, Kelch like 12 antibody, Kelch like 12 variant antibody, Kelch like protein 12 antibody, Kelch like protein C3IP1 antibody, kelch-like family member 12 antibody, Kelch-like protein 12 antibody, KLH12_HUMAN antibody, KLHL 12 antibody, klhl12 antibody, OTTHUMP00000038799 antibody

UniProt: Q53G59