KLHL22 antibody (AA 2-300) (FITC)

Catalog No. ABIN7157283

The Rabbit Polyclonal anti-KLHL22 antibody has been validated for . It is suitable to detect KLHL22 in samples from Human.

Quick Overview for KLHL22 antibody (AA 2-300) (FITC) (ABIN7157283)

Target: KLHL22 (Kelch-Like 22 (KLHL22))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLHL22 antibody is conjugated to FITC

Application: Please inquire

Product Details anti-KLHL22 Antibody (FITC)

Binding Specificity: AA 2-300

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Kelch-like protein 22 protein (2-300AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KLHL22

Target: KLHL22 (Kelch-Like 22 (KLHL22))

Alternative Name: KLHL22

Background:

Background: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.

Aliases: KLHL22Kelch-like protein 22 antibody

UniProt: Q53GT1