KIDINS220 antibody (AA 1077-1370)

Catalog No. ABIN7157550

The Rabbit Polyclonal anti-KIDINS220 antibody has been validated for WB, ELISA, IHC and IF. It is suitable to detect KIDINS220 in samples from Human.

Quick Overview for KIDINS220 antibody (AA 1077-1370) (ABIN7157550)

Target: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIDINS220 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-KIDINS220 Antibody

Binding Specificity: AA 1077-1370

Purpose: KIDINS220 Antibody

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Kinase D-interacting substrate of 220 kDa protein (1077-1370AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KIDINS220

Target: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Alternative Name: KIDINS220

Background:

Background: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

Aliases: Ankyrin repeat-rich membrane-spanning protein antibody, arms antibody, KDIS_HUMAN antibody, kidins220 antibody, Kinase D interacting substance of 220 kDa antibody, Kinase D-interacting substrate of 220 kDa antibody, rgd 619949 antibody

UniProt: Q9ULH0