KNG1 antibody (AA 390-644) (Biotin)

Catalog No. ABIN7157682

The Rabbit Polyclonal anti-KNG1 antibody has been validated for IHC and ELISA. It is suitable to detect KNG1 in samples from Human.

Quick Overview for KNG1 antibody (AA 390-644) (Biotin) (ABIN7157682)

Target: KNG1 (Kininogen 1 (KNG1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KNG1 antibody is conjugated to Biotin

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-KNG1 Antibody (Biotin)

Binding Specificity: AA 390-644

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Kininogen-1 protein (390-644AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KNG1

Target: KNG1 (Kininogen 1 (KNG1))

Alternative Name: KNG1

Background:

Background: Kininogens are inhibitors of thiol proteases, (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes, (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action), (5) LMW-kininogen inhibits the aggregation of thrombocytes, (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Aliases: Alpha-2-thiol proteinase inhibitor antibody, BDK antibody, BK antibody, Bradykinin antibody, Bradykinin included antibody, Fitzgerald factor antibody, FLAUJEAC FACTOR antibody, High molecular weight kininogen antibody, HMWK antibody, Ile-Ser-Bradykinin antibody, Kallidin I antibody, Kallidin II antibody, KNG antibody, KNG1 antibody, KNG1_HUMAN antibody, Low molecular weight growth-promoting factor antibody, WILLIAMS FACTOR antibody, Williams-Fitzgerald-Flaujeac factor antibody

UniProt: P01042

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process