L3MBTL1 antibody (AA 513-752)

Catalog No. ABIN7158005

This Rabbit Polyclonal antibody specifically detects L3MBTL1 in IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for L3MBTL1 antibody (AA 513-752) (ABIN7158005)

Target: L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This L3MBTL1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-L3MBTL1 Antibody

Binding Specificity: AA 513-752

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Lethal(3)malignant brain tumor-like protein 1 protein (513-752AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for L3MBTL1

Target: L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Alternative Name: L3MBTL1

Background:

Background: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a \\\'reader\\\' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at \\\'Lys-26\\\' (H1bK26me1 and H1bK26me2) and histone H4 at \\\'Lys-20\\\' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at \\\'Lys-382\\\', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at \\\'Lys-860\\\'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.

Aliases: dJ138B7.3 antibody, H-L(3)MBT antibody, H-l(3)mbt protein antibody, KIAA0681 antibody, L(3)mbt protein homolog antibody, L(3)mbt-like antibody, L3MBT antibody, L3MBTL antibody, L3MBTL1 antibody, Lethal (3) malignant brain tumor l(3 antibody, Lethal(3)malignant brain tumor-like protein 1 antibody, LMBL1_HUMAN antibody, RGD1307316 antibody, ZC2HC3 antibody

UniProt: Q9Y468

Pathways: Chromatin Binding