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LIM Domain Kinase 1 antibody (AA 179-320) (FITC)

This Rabbit Polyclonal antibody specifically detects LIM Domain Kinase 1 in . It exhibits reactivity toward Human.
Catalog No. ABIN7158356

Quick Overview for LIM Domain Kinase 1 antibody (AA 179-320) (FITC) (ABIN7158356)

Target

See all LIM Domain Kinase 1 (LIMK1) Antibodies
LIM Domain Kinase 1 (LIMK1)

Reactivity

  • 105
  • 79
  • 73
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Host

  • 101
  • 20
  • 3
Rabbit

Clonality

  • 104
  • 20
Polyclonal

Conjugate

  • 59
  • 9
  • 7
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
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  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
This LIM Domain Kinase 1 antibody is conjugated to FITC

Application

Please inquire
  • Binding Specificity

    • 23
    • 15
    • 15
    • 8
    • 7
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 179-320

    Cross-Reactivity

    Human

    Purification

    >95%, Protein G purified

    Immunogen

    Recombinant Human LIM domain kinase 1 protein (179-320AA)

    Isotype

    IgG
  • Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C,-80 °C

    Storage Comment

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    LIM Domain Kinase 1 (LIMK1)

    Alternative Name

    LIMK1

    Background

    Background: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).

    Aliases: EC 2.7.11.1 antibody, LIM domain kinase 1 antibody, LIM motif-containing protein kinase antibody, LIMK antibody, LIMK-1 antibody, limk1 antibody, LIMK1_HUMAN antibody

    UniProt

    P53667

    Pathways

    Caspase Cascade in Apoptosis, Regulation of Cell Size, CXCR4-mediated Signaling Events
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