LRP6 antibody (AA 20-150)

Catalog No. ABIN7158577

This anti-LRP6 antibody is a Rabbit Polyclonal antibody detecting LRP6 in IHC and ELISA. Suitable for Human.

Quick Overview for LRP6 antibody (AA 20-150) (ABIN7158577)

Target: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRP6 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-LRP6 Antibody

Binding Specificity: AA 20-150

Purpose: LRP6 Antibody

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Low-density lipoprotein receptor-related protein 6 protein (20-150AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for LRP6

Target: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Alternative Name: LRP6

Background:

Background: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).

Aliases: ADCAD2 antibody, C030016K15Rik antibody, Cd antibody, FLJ90062 antibody, FLJ90421 antibody, LDL receptor related protein 6 antibody, Low density lipoprotein receptor related protein 6 antibody, Low-density lipoprotein receptor-related protein 6 antibody, LRP-6 antibody, LRP6 antibody, LRP6_HUMAN antibody, OTTHUMP00000238979 antibody, OTTHUMP00000238980 antibody, OTTHUMP00000238982 antibody, STHAG7 antibody

UniProt: O75581

Pathways: WNT Signaling, Tube Formation