RIKEN cDNA 4930404A10 Gene (4930404A10RIK) (AA 18-91) antibody (Biotin)
Quick Overview for RIKEN cDNA 4930404A10 Gene (4930404A10RIK) (AA 18-91) antibody (Biotin) (ABIN7159184)
Target
See all RIKEN cDNA 4930404A10 Gene (4930404A10RIK) AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 18-91
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Cross-Reactivity
- Human
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Purification
- >95%, Protein G purified
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Immunogen
- Recombinant Human Meiosis-specific kinetochore protein (18-91AA)
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Isotype
- IgG
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anti-RIKEN cDNA 4930404A10 Gene (4930404A10RIK) (AA 18-91) antibody
4930404A10RIK Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- RIKEN cDNA 4930404A10 Gene (4930404A10RIK)
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Alternative Name
- MEIKIN
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Background
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Background: Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis.
Aliases: MEIKINMeiosis-specific kinetochore protein antibody
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UniProt
- A0A087WXM9
Target
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