MACF1 antibody (AA 1936-2150) (Biotin)

Catalog No. ABIN7159743

The Rabbit Polyclonal anti-MACF1 antibody has been validated for ELISA. It is suitable to detect MACF1 in samples from Human.

Quick Overview for MACF1 antibody (AA 1936-2150) (Biotin) (ABIN7159743)

Target: MACF1 (Microtubule-Actin Crosslinking Factor 1 (MACF1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MACF1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-MACF1 Antibody (Biotin)

Binding Specificity: AA 1936-2150

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 protein (1936-2150AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MACF1

Target: MACF1 (Microtubule-Actin Crosslinking Factor 1 (MACF1))

Alternative Name: MACF1

Background:

Background: Isoform 2 is a F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells (By similarity).

Aliases: MACF1 antibody, ABP620 antibody, ACF7 antibody, KIAA0465 antibody, KIAA1251 antibody, Microtubule-actin cross-linking factor 1 antibody, isoforms 1/2/3/5 antibody, 620 kDa actin-binding protein antibody, ABP620 antibody, Actin cross-linking family protein 7 antibody, Macrophin-1 antibody, Trabeculin-alpha antibody

UniProt: Q9UPN3