SMCR7L antibody (AA 51-309) (Biotin)

Catalog No. ABIN7159854

The Rabbit Polyclonal anti-SMCR7L antibody has been validated for ELISA. It is suitable to detect SMCR7L in samples from Human.

Quick Overview for SMCR7L antibody (AA 51-309) (Biotin) (ABIN7159854)

Target: SMCR7L (Smith-Magenis Syndrome Chromosome Region, Candidate 7-Like (SMCR7L))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMCR7L antibody is conjugated to Biotin

Application: ELISA

Product Details anti-SMCR7L Antibody (Biotin)

Binding Specificity: AA 51-309

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Mitochondrial dynamics protein MID51 protein (51-309AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SMCR7L

Target: SMCR7L (Smith-Magenis Syndrome Chromosome Region, Candidate 7-Like (SMCR7L))

Alternative Name: MIEF1

Background:

Background: Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.

Aliases: MIEF1 antibody, MID51 antibody, SMCR7L antibody, Mitochondrial dynamics protein MID51 antibody, Mitochondrial dynamics protein of 51 kDa antibody, Mitochondrial elongation factor 1 antibody, Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like antibody, SMCR7-like protein antibody

UniProt: Q9NQG6