CHCHD4 antibody (AA 1-142)

Catalog No. ABIN7159923

The Rabbit Polyclonal anti-CHCHD4 antibody has been validated for ELISA and IHC. It is suitable to detect CHCHD4 in samples from Human.

Quick Overview for CHCHD4 antibody (AA 1-142) (ABIN7159923)

Target: CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHCHD4 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-CHCHD4 Antibody

Binding Specificity: AA 1-142

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Mitochondrial intermembrane space import and assembly protein 40 protein (1-142AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CHCHD4

Target: CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))

Alternative Name: CHCHD4

Background:

Background: Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system.

Aliases: CHCHD4 antibody, MIA40Mitochondrial intermembrane space import and assembly protein 40 antibody, Coiled-coil-helix-coiled-coil-helix domain-containing protein 4 antibody

UniProt: Q8N4Q1