ZFP36L2 antibody (AA 219-321)

Catalog No. ABIN7160264

This Rabbit Polyclonal antibody specifically detects ZFP36L2 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for ZFP36L2 antibody (AA 219-321) (ABIN7160264)

Target: ZFP36L2 (Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZFP36L2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ZFP36L2 Antibody

Binding Specificity: AA 219-321

Purpose: ZFP36L2 Antibody

Cross-Reactivity: Rat

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human mRNA decay activator protein ZFP36L2 protein (219-321AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ZFP36L2

Target: ZFP36L2 (Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2))

Alternative Name: ZFP36L2

Background:

Background: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510). Acts as a 3\\\'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3\\\'-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA.

Aliases: BRF2 antibody, Butyrate response factor 2 antibody, C3H1 type-like 2 antibody, EGF response factor 2 antibody, EGF-response factor 2 antibody, ERF 2 antibody, ERF-2 antibody, ERF2 antibody, Protein TIS11D antibody, RNF162C antibody, TIS11D antibody, TISD_HUMAN antibody, ZFP36 like 2 antibody, ZFP36 ring finger protein like 2 antibody, ZFP36-like 2 antibody, Zfp36l2 antibody, Zinc finger protein 36 antibody, Zinc finger protein 36, C3H type like 1 antibody, zinc finger protein 36, C3H type like 2 antibody, Zinc finger protein 36, C3H1 type like 2 antibody, Zinc finger protein, C3H type, 36 like 2 antibody

UniProt: P47974

Pathways: Stem Cell Maintenance