MYL2 antibody (AA 8-164) (HRP)

Catalog No. ABIN7160554

Product Details anti-MYL2 Antibody (HRP)

Target: MYL2 (Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2))

Binding Specificity: AA 8-164

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYL2 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Myosin regulatory light chain 2, ventricular/cardiac muscle isoform protein (8-164AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MYL2

Target: MYL2 (Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2))

Alternative Name: MYL2 (MYL2 Products)

Background:

Background: Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion, as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force. During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly.

Aliases: Cardiac myosin light chain-2 antibody, Cardiac ventricular myosin light chain 2 antibody, CMH10 antibody, MLC 2v antibody, MLC-2 antibody, MLC-2v antibody, MLC2 antibody, MLRV_HUMAN antibody, MYL 2 antibody, MYL2 antibody, Myosin light chain 2 regulatory cardiac slow antibody, Myosin light polypeptide 2 regulatory cardiac slow antibody, Myosin regulatory light chain 2 antibody, Myosin regulatory light chain 2 ventricular/cardiac muscle isoform antibody, Regulatory light chain of myosin antibody, RLC of myosin antibody, Slow cardiac myosin regulatory light chain 2 antibody, ventricular/cardiac muscle isoform antibody

UniProt: P10916

Pathways: Myometrial Relaxation and Contraction