DMPK antibody (AA 243-424) (Biotin)

Catalog No. ABIN7160624

This Rabbit Polyclonal antibody specifically detects DMPK in ELISA. It exhibits reactivity toward Human.

Quick Overview for DMPK antibody (AA 243-424) (Biotin) (ABIN7160624)

Target: DMPK (Dystrophia Myotonica-Protein Kinase (DMPK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DMPK antibody is conjugated to Biotin

Application: ELISA

Product Details anti-DMPK Antibody (Biotin)

Binding Specificity: AA 243-424

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Myotonin-protein kinase protein (243-424AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DMPK

Target: DMPK (Dystrophia Myotonica-Protein Kinase (DMPK))

Alternative Name: DMPK

Background:

Background: Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.

Aliases: DM 1 antibody, DM antibody, DM kinase antibody, DM protein kinase antibody, DM-kinase antibody, DM1 antibody, DM1 protein kinase antibody, DM1PK antibody, DMK antibody, DMPK antibody, DMPK_HUMAN antibody, Dystrophia myotonica 1 antibody, Dystrophia myotonica protein kinase antibody, MDPK antibody, MT PK antibody, MT-PK antibody, Myotonic dystrophy associated protein kinase antibody, Myotonic dystrophy protein kinase antibody, Myotonin protein kinase A antibody, Myotonin protein kinase antibody, Myotonin-protein kinase antibody, Thymopoietin homolog antibody

UniProt: Q09013

Pathways: Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development